15 , 16 , 17 In the United States and much of the developed world, cataract surgery, albeit costly, is readily available and routinely successful in restoring sight
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A 2019 study in the Journal of Investigative Dermatology further confirmed the mechanism by which 4-substituted phenols selectively destroy melanocytes
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This synergistic effect amplifies its therapeutic potential
Possible reasons include the Washington State University patent holders not finding a pharmaceutical company willing to invest in development, the cancer biology concern with c-Met activation making development companies cautious, the preclinical effect sizes in rats not justifying the expense and risk of human trials, or other factors specific to drug development economics
