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Factors Influencing Smokeless Tobacco Use in Rural Ohio Appalachia

The high THC concentrations found in vape products intensify these risks compared to traditional marijuana use

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While tobacco is a plant, many global manufacturers utilize animal-tested filtering materials, shellac (derived from insects) as an adhesive casing agent, or castoreum (beaver extract) as a premium top-aroma enhancer, making certified raw native leaves the preferred choice for vegan smokers

Phyto molecules like EGCG reduces cytokine synthesis via activation of the Nrf2/HO-1 pathway (Kim et al