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This remarkable feature is unique to ArsR family sensors among all of the metalloregulatory protein families discussed here

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Human studies mainly used short-term intravenous DSIP injections under controlled research conditions, typically at 25 nmol/kg, but these studies were small, short-duration, and not designed to establish long-term safety or optimal dosing

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However, other post-translational modifications have gained increasing importance, such as oxidation, ubiquitination, SUMOylation or glutathionylation