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There was a statistically significant difference found in the secondary outcome of the total hangover difference (NAC sumPlacebo sum) based on gender, with the female hangover difference of 3.5, and the male hangover difference of + 2 ( P = 0.04)

For most researchers with normal pituitary function, this is not a concern

Lancet 377:19291937 Creager MA, Olin JW, Belch JJ, Moneta GL, Henry TD, Rajagopalan S, Annex BH, Hiatt WR (2011) Effect of hypoxia-inducible factor-1alpha gene therapy on walking performance in patients with intermittent claudication

Supplementing with GHRH may have the opposite effect

Chou TC, Talalay P

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