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The total flushing volume should not be too large to prevent microbial damage

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The brains restricted antioxidant capacity, high energy demand, high levels of transition metals, such as iron and copper, and a high concentration of polyunsaturated fatty acids which can be subjected to lipid peroxidation [103,104,105] make the nervous system particularly vulnerable to oxidative stress [106]

The latter compound can be fully catabolized or serve as the precursor for NAD + synthesis