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Research documents morphological changes in epicardial tissue following TB-500 administration, with changes resembling embryonic characteristics

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When they knocked out the protein and stopped it from working, the cells were less round, and less able to grow and invade

However, conventional small-molecule drugs and biologic macromolecules (e.g., antibodies) exhibit extremely low delivery efficiency to the fundus, typically less than 0.01%, due to multiple barriers, including the cornea, tear drainage, and the BRB [21]