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At higher concentrations, cocaine also blocks different voltage gated channels in a state-dependent manner with a higher affinity for inactivated and open states vs rested/closed states of the channels

Ncbi.nlm.nih.gov: 244251

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[26] [27] [28] Peer-reviewed studies have quantified microfiber shedding from cigarette filters in water over time, reporting average releases of ~5.7892.43 microfiber items per gram of filter after 160 days, and estimating that cigarette filters may release tens of trillions of microfibers annually into aquatic environments

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