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10.1056/NEJMoa1611770 5 AultA

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A deficiency in vitamin B12 can lead to symptoms such as fatigue, brain fog, irritability, tingling sensations in the extremities, and even depression

Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation

These cells integrate into the ovarian tissue, modulating the expression of essential cellular markers by significantly increasing epithelial markers (cytokeratin 7) and estrogen receptors (ER), while concurrently decreasing mesenchymal markers (fibronectin and vimentin), thus reversing the ovarian fibrosis associated with POF

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