The current consensus is that macrophages recruited into the gut in IBD have a greater pro-inflammatory potential than resident macrophages, and this would support the notion that increased sensitivity of the recruited cells to pro-death signals could limit inflammation, while the opposite could be envisaged for resident macrophages
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So I just give them extra glutathione to make sure that they are able to use up right now, because when you have a problem today, if you need the money today, and if you give you a job, I said, that's good, but I need the money now
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The astroglia regulates the extracellular glutamate concentration maintained at approximately 13 mM to maintain a sufficient signal-to-noise ratio in glutamate transmission [162] and to minimize the risk of excitotoxic actions of glutamate on neurons [163]
Mechanistically, we find that GSH promotes lipid abundance by repressing NRF2, a transcription factor induced by oxidative stress
