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doi: 10.1007/s12640-022-00627-y 177 Pedraz-PetrozziB.SardinhaH.GillesM.DeuschleM

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p53 is one of the main factors that orchestrates apoptosis in response to DNA damage, and it controls the fate of hematopoietic cells deficient in both the Fanconi Anaemia ICL DNA repair pathway and the aldehyde-metabolizing enzyme Aldh2 in mice 13

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2) Activation of endothelial cells and disruption of tight junction proteins within the neurovascular unit may result in persistent dysfunction of the BBB (129)