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While set in California, the entire movie, save for the ending scene at Dodger Stadium in Los Angeles, was shot in Utah, specifically the cities of Midvale, Salt Lake, and Ogden

Isaiah 55:2 Why do you spend money on what cannot nourish you and your wages on what does not satisfy you

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This means that half of the patients diagnosed with IBS by Rome III would not be diagnosed with IBS by Rome IV