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The unique pharmacological profile of tirzepatide allows a greater engagement of the GIP receptor, mimicking the actions of native GIP, compared to the GLP-1 receptor, where it activates biased downstream signals favoring cAMP generation over beta-arrestin recruitment, resulting in reduced receptor internalization and degradation 2

Y.et al (2014)

Epilepsia 55 , 475482 (2014)

(2016) Miscellaneous pathogens In Bacterial Fish Pathogens, Springer International Publishing Switzerland, pp

References Sourced from Neelakantan et al., Biochemical Pharmacology (2018), on NNMT inhibitors reversing diet-induced obesity in mice