Safety and tolerability of putaminal AADC gene therapy for Parkinson disease
These receptor-specific dynamics suggest altered signaling profiles compared to other amylin-based peptides
In vitro findings highlighted the efficacy of DP in suppressing inflammation, ferroptosis, and oxidative stress via activation of Nrf2pathway
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This is supported by studies using neurons differentiated from patient-derived induced pluripotent stem cells (iPSC), which were found to display hyperexcitability and increased intracellular Ca 2+ levels, as well as increased transcription of genes involved in Ca 2+ -signalling, compared with neurons derived from healthy unaffected controls [19, 20]
Di Nardo L, Pellegrini C, Di Stefani A, Ricci F, Fossati B, Del Regno L, et al