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5.2 Parkinsons disease Parkinsons disease is the second most common chronic and late-onset neurodegenerative disease after Alzheimers disease, with clinical features including slowness of facial expression, increased muscle tension throughout the body, bradykinesia, progressive resting tremor, and dementia (Heusinkveld et al., 2018)
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Its present in every body cell and has been linked to healthynerve function and reduced blood sugar levels
For oral administration in mice, NR and NMN are first metabolized by the liver or GI tract into NAM, which can then be taken up by other tissues