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It has a 1620 hour half-life and is commonly detectable for 24 days after last use, and sometimes longer in frequent/heavy users

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More than 50 variants of CYP2A6 have been identified, many of which result in decreased nicotine metabolism (see The relationship of CYP2A6 genotype to nicotine metabolism and smoking intensity (measured by TNE) has been demonstrated in two lung cancer studies

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