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Many eczema patients react to fragrances, preservatives, or emulsifiers commonly found in commercial skincare products

These include: Lifestyle interventions (dietary advice, physical activity programmes) Licensed pharmacotherapy such as orlistat, or GLP-1 receptor agonists including semaglutide 2.4 mg (Wegovy, NICE TA875) or tirzepatide (Zepbound) where clinically indicated and available Referral to tier 3 or tier 4 weight management services , including bariatric surgery assessment where appropriate Information on NHS weight management services and eligibility for licensed treatments is available via the NHS website and NICE guidance

If you respond well to 5 mg but 10 mg causes significant side effects, the 7.5 mg step provides a middle ground that semaglutide simply does not offer

Baseline measurements before starting, periodic monitoring during use, and follow-up assessment after cycling off provide data points that can reveal individual response patterns

Distribution of data normality was tested by the KolmogorovSmirnov test