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in TCC, GSTP1 should be considered as a potential therapeutic target This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access $189.00 per year only $15.75 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF

While general practice-based data are a valuable source for population-level studies 47 , such limitations may bias absolute risk estimates and should be considered when interpreting results

doi: 10.1016/j.cmet.2020.10.011 26 GaoMMonianPQuadriNRamasamyRJiangX

Studies have shown that hypoxia (1% O2 for 24 h) upregulates CAV-1 transcription through activation of NRF1 in endothelial cells, which induces internalization of claudin-5 and autophagic degradation, and accordingly, these effects lead to BBB disruption and trigger HACE (Xue et al., 2022)

Gamma PGA is a 100% natural Japanese ingredient derived from Natto

Ritenbaugh, C