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However, when the extent of hepatocyte damage exceeds their capacity for self-replication, other liver cells are activated to undergo dedifferentiation or transdifferentiation, thereby compensating for the lost tissue
The entire dose enters circulation immediately, overwhelming peptidase capacity momentarily before rapid enzymatic degradation and renal filtration eliminate the compound
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Using tissue from donors, the team observed that cells in the nucleus pulposus, a jelly-like structure at the center of intervertebral discs, had a lower amount of this peptide receptor when degeneration increased
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