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But many brain-active peptides are specifically designed to cross that barrier, and any contaminants that co-cross with them have direct access to neural tissue

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Several groups have demonstrated that continuous systemic administration of rotenone to rats and mice reproduces key features of PD, including selective degeneration of the nigrostriatal dopaminergic system, activation of astroglia and microglia, formation of cytoplasmic inclusions in neurons, movement disorders, and defects in mitochondrial complex I [11, 14, 57, 62-64]

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The clinical results are frankly remarkable

The drug has not been granted approval by Australia's Therapeutic Goods Administration, or any other health authority in the world, for human use and is therefore banned by the World Anti-Doping Agency