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however, once the balance between ROS production and clearance is disrupted, excessive ROS generation can lead to heightened oxidative stress (17)

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10.1038/nm0898-901 92

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Yan SD, Schmidt AM, Anderson GM, Zhang J, Brett J, Zou YS, Pinsky D, Stern D: Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins