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In a mouse model of diet-induced NASH, Notch signaling in hepatocytes induces osteopontin secretion, paracrine HSC activation and hepatic fibrosis, which are abrogated by Notch inhibition (132)

Furthermore, Luo et al

Dihexa reversed cognitive deficits induced by scopolamine (an anticholinergic agent) in rodent models, suggesting relevance to cholinergic aspects of cognitive impairment

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