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For perioperative or critically ill patients, determining the exact dose can be challenging because of metabolic instability and inflammatory states

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It has diverse physiological functions, including protection against reactive oxygen species and nitrogen species, antioxidant defense as well as maintenance of cellular thiol status

A recent experiment verified that fenofibrate affected ferroptosis-related signaling pathways to protect kidney function from DKD, and Nrf2 was confirmed to act a significant role in the process of mitigation[88]

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