Swanson JM et al (1999): Acute tolerance to methylphenidate in the treatment of ADHD in children
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After a warning letter from the FDA was issued in July 2020, there was a subsequent debate on whether or not NAC should be sold as a supplement, because it had previously been approved for use as a drug in 1963
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Figure 2 More recently, a multiple hits theory has been proposed, with the addition of other pathogenic factors in NAFLD development: low-grade chronic inflammation, genetic and epigenetic mutations, and intestinal microbiota
