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In vitro studies showed that DHLA in addition to Co 2+ , Ni 2+ , Cd 2+ , Cu 2+ , Zn 2+ , Pb 2+ , and Hg 2+ also chelates Fe 3+ (its complex is more stable than that formed with Fe 2+ ), whereas ALA preferentially binds Mn 2+ , Cu 2+, Zn 2+ , and Pb 2+ but cannot chelate Fe 3+ [14,15]

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[12] Kurkin DV, Bakulin DA, Morkovin EI, Kalatanova AV, Makarenko IE, Dorotenko AR, Kovalev NS, Dubrovina MA, Verkholyak DV, Abrosimova EE, Smirnov AV, Shmidt MV, Tyurenkov IN

A failure in energy metabolism and antioxidant uptake precede symptoms of Huntington's disease in mice

Molecular Pathways BPC-157 significantly promotes angiogenesis by enhancing vascular endothelial growth factor receptor-2 (VEGFR2) activity and nitric oxide (NO) signaling primarily through activation of the Akt-endothelial nitric oxide synthase (eNOS) pathway