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Notably, the liver is a major target organ for the metabolic effects of insulin and exerts a first-pass extraction of up to 85% of insulin delivered by the portal vein ( Figure 1A )

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Other works have shown that glutathione-ethyl ester is able to effectively prevent oxidative damage of mitochondrial complex I caused by ischemia/reperfusion and thereby reduces the infarct size and improved neurological outcome [34, 35]

The role of the GABAergic system in diseases of the central nervous system

doi: 10.1038/s41418-018-0251-z 158 WanWQianCWangQLiJZhangHWangLet al

A detailed clinical evaluation is conducted to review medical history, prior injuries, surgeries, medications and existing health conditions