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Pregnant or nursing mothers on these diets may also need extra B12 support

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No maximum safe dose has yet been determined, but as a general rule, it's well-tolerated, although some do experience gastrointestinal side effects such as nausea, diarrhea or constipation

1 Mechanistically, treatment raised the Bcl-2/Bax ratio and reduced apoptosis markers (cleaved caspase-3 and PARP) in the dermal papilla cells, elevated VEGF production, and decreased TGF-1 secretion from dermal fibroblasts

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