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The satiety effect is additive with GLP-1 agonism because the pathways don't overlap which is why CagriSema outperforms semaglutide monotherapy and tirzepatide on some endpoints

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Even if the pathophysiology of both conditions is not fully elucidated and not identical, the role of an impaired intestinal barrier function and altered microbiota in the pathogenesis and progression of chronic liver disease is increasingly recognized as a key player