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Side Effects and Safety: What the Research Shows Available experimental and review data describe GHKCu as noncytotoxic and welltolerated in cell and animal studies (including injectable and topical models) with no significant adverse effects reported at typical research doses

Cochrane handbook for systematic reviews of interventions version 6.2 (updated February 2021)2021

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Direct stamping on the thin tissue immediately beneath the eye is not appropriate at home

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Others feel no immediate pain relief and conclude the peptide did not work. Both interpretations can be flawed