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Gut microbiota dysbiosis and immune activation can further enhance IDO activity, exacerbating the conversion of tryptophan to KYNA

(Source 1) Vitamin C supplementation also increases Bifidobacteria , a genus of beneficial bacteria in the gut, and positively modulates the microbiome

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What is AOD9604 commonly studied for

This metabolic shift is bidirectionally linked to epigenetic regulation: epigenetic modifiers directly control metabolic enzyme expression, while metabolites such as -ketoglutarate and S-adenosylmethionine serve as cofactors for histone/DNA-modifying enzymes