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Typical effective doses range from 5001000mg daily, taken on an empty stomach to maximise absorption

GABA is the primary inhibitory neurotransmitter in the central nervous system, playing a central role in regulating cell-to-cell communication

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Dose-response analysis indicates optimal benefits occur after approximately 50 weeks of continuous supplementation, suggesting long-term metabolic remodeling rather than acute effects

Mechanistically, mtDNA is unevenly distributed in daughter mitochondria during fission, potentially reducing transcription of respiratory complex-related proteins and leading to excessive mtROS production [91]