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Along these lines, an emerging theory linking excitotoxicity and mitochondrial dysfunction suggests that an accumulation of lactate, a metabolic byproduct which is toxic (especially to nerve cells) at high concentrations may play a role in ALS progression (Vadakkadath Meethal 2012)
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The roles of complexes III and IV in apoptosis are less clear, but the electron carrier between the two complexes, cyt c , has been known as a key player by activating apoptosis protease activating factor-1 (Apaf-1) when released to the cytosol
Declaration of Interest SJ has no conflicts of interest to declare
Scientific interest in GHK-Cu continues to expand due to its role in research involving copper-associated signaling networks, extracellular matrix dynamics, and cellular communication pathways
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