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In contrast, helix 3 in ironsulfur cluster-binding monothiol glutaredoxins contains a bulky tryptophan residue in a WP-motif that sticks out on the protein surface 3

We are currently investigating the safety and feasibility of a combination of gemcitabine and nab-paclitaxel with oral L-glutamine powder as a first-line systemic therapy in patients with unresectable or metastatic PDAC (GlutaPanc phase I trial [124])

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This includes increased phosphorylation of dynamin-related protein 1 (DRP1) at serine-616, promoting mitochondrial fragmentation, and decreased expression of fusion proteins such as mitofusins (MFN1/2) and optic atrophy 1 (OPA1) (Vaccaro et al., 2020

The skin as examined under the microscope demonstrates mild thickening and perforation of the hair follicle