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Ketone bodies and ketogenic diets may exert neuroprotective effects by enhancing anti-apoptotic and antioxidant defences (e.g., via inhibition of mPTP opening, mitochondrial ROS production, and caspase activation, and activation of SIRT1/2/3PGC1FOXO1/3a and ERK/CREB/eNOS pathways, with Nrf2 engagement), and by modulating NAD-dependent signalling and epigenetic/post-translational regulation (including HDAC/p300-mediated histone modifications) that can upregulate neurotrophic programs such as BDNF expression [69]

Falling asleep was fine, but I kept waking up at 2 or 3 AM and then just lying there, staring at the ceiling until my alarm went off

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In the adult brain, BDNF also supports neurogenesis in the hippocampal dentate gyrus, one of the few brain regions where new neurons continue to form throughout life

Based on the functional differences, CD can be divided into accidental cell death (ACD) and regulated cell death (RCD)