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Most research suggests cumulative exposure over time is more important than precise timing

J Exp Bot 53:111 Hasanuzzaman M, Fujita M (2011) Selenium pretreatment up-regulates the antioxidant defense and methylglyoxal detoxification system and confers enhanced tolerance to drought stress in rapeseed seedlings

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Calorie restriction modulates the transcription of genes related to stress response and longevity in human muscle: The CALERIE study

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