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PMID: 42016821 Toxicol Res (Camb)2025 Nov 7;14(6):tfaf152

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doi: 10.1016/S0140-6736(17)31472-1 4 MagtanongLKoPJToMCaoJYForcinaGCTarangeloAet al

So administering native IGF-1 in a research protocol means working with a compound thats rapidly cleared and rapidly sequestered

If you notice these symptoms after increasing your dose, it is a sign that your body isn't absorbing the excess and you should consider lowering the amount or switching to a more bioavailable format