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The early cig-a-like vape pens were self-contained and this meant that the pen did not have any options that would allow you to change the flavor and nicotine strength of the liquid already in the tank

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If left untreated, this condition can progress to gum disease that spreads to underlying tissue and bone (periodontitis), a much more serious condition that can lead to tooth loss

Additional reflections on other quality issues applying only to individual, or a subset of, studies are in online supplemental appendix S3