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clinicians should emphasize integrated dietary patterns and risk-factor control (blood pressure, inflammation, insulin sensitivity) while addressing sleep, stress, and environmental exposures that affect brain function and attention circuitry

Regulation of autophagy by ROS: physiology and pathology

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Aging, poor diet, chronic illness, stress, sleep deprivation, and exposure to toxins can all contribute to low glutathione over time

The loading/maintenance pattern evolved from decades of underground use: early protocols (1990s) used higher doses with more side effects

Although the pKa value of Cys-thiol GSH is relatively high (8.99.4) [3], indicating low reactivity in the intracellular environment, its central role in protecting cells from reactive oxygen/nitrogen species (RONS) is based on enzyme-catalyzed reactions, efficient recycling pathways, as well as the mass effect achieved by its high intracellular concentrations (210 mM)