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You must be consistent for at least 3-5months in order to see results

Rapamycin exerts anti-ferroptotic effects by decreasing transferrin receptor expression, reducing cellular iron content, and activating the iron-regulated protein-1/2 (Irp1/2) system, potentially compensating for transferrin downregulation to maintain iron homeostasis (69)

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Factors affecting timeline include starting condition (more damaged skin may take longer to show gains), dosage (higher doses may produce faster results), consistency (daily use produces better results than sporadic use), and personal response (some people respond faster than others)