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[48:52] Ilene Ruhoy M.D

It's a small variable that can have a surprisingly large ripple effect

Alkaloids such as isoliensinine can inhibit the TGF-1/Smad2/3 signaling pathway in hypertensive-associated renal fibrosis, while the berberine alkaloid has shown suppression of the NFB signaling pathway in renovascular complications [241, 242]

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No studies to date have verified their safety for use in humans