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however, there are scenarios where inhibiting SIRT3 might be beneficial 181

IGF-1 LR3 and Glucose Metabolism Research In differentiated 3T3-L1 adipocytes, IGF-1 LR3 was used to investigate IGFBP-independent IGF-1R-mediated glucose uptake pathways, with research confirming that its effects on glucose transport are mediated directly through the IGF-1 receptor rather than through IGFBP modulation providing a clean experimental tool for dissecting receptor-specific metabolic signalling

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Gomez DR, Cox JD, Roth JA, Allen PK, Wei X, Mehran RJ, Kim JY, Swisher SG, Rice DC , Komaki R

This is in agreement with a recent study by Eissa et al