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This larger-quantity format provides increased material availability for research facilities conducting extended studies, multi-phase experiments, or repeated laboratory protocols
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In recent studies, HLA-A*33:01 was associated with DILI due to ticlopidine (OR, 163.1), methyldopa (OR, 97.8), fenofibrate (OR, 58.7), terbinafine (OR, 40.5), enalapril (OR, 34.8), sertraline (OR, 29), and erythromycin (OR 10.2) in GWASs of persons of European descent
This is crucial for understanding the proteoform concept (Smith et al., 2013) highlighting the idea that the complexity of biological systems is not solely dictated by their genome size, but rather by the vast and functionally diverse proteome, consisting of a multitude of unique proteoforms derived from a relatively small number of genes (Schluter et al., 2009)