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In answer to the more direct question of how much nicotine per day is safe, a reasonable starting point might be, "How much nicotine might it take to poison someone?" The ECHA currently gives an "acute toxicity estimate" (ATE) for nicotine via the oral route to be 5 mg/kg bw [7] , meaning 5mg of nicotine for every kilogram of bodyweight of the person consuming the nicotine

1960 Global sales exceed 280 billion cigarettes with trading profits of more than 58 million

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Nicotine is considered a drug no matter the source you get it from

Since no corrections to the questionnaire were required, the ten preliminary questionnaires were included in the primary data analysis

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