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Klotho levels decline significantly with age: young adults (18-35) have the highest levels, with progressive decreases through middle age and into older adulthood

Identification and functions of usefully disordered proteins, in Advances in Protein Chemistry , Elsevier, 2002, pp

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In the United States it is not approved for any medical use

Wrinkle Reduction One randomised, double-blind clinical trial found over 30% improvement in wrinkles in 8 weeks, compared to both an alternative peptide complex (Matrixyl 3000) and a control serum

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