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What they found: Cagrilintide 4.5 mg: 10.8 % weight reduction vs 3.0 % placebo (p 40 % of patients achieved 25 % weight reduction , historically unprecedented Safety profile in line with Phase 2 data Why it matters: REDEFINE 1 confirmed CagriSema as the largest body-weight signal reported in the published incretin literature to date

However, metformin can cross the placenta into the fetus, which has raised concerns about its safety and potential adverse effects

Ling S-C, Polymenidou M, Cleveland DW (2013) Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis

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Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8