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Studies have shown that the NLRP3 inflammasome is also involved in other skin diseases, such as psoriasis, urticaria, and bullous pemphigoid (179)

It has been well established that Abeta, when incubated with copper and oxygen, produces H 2 O 2 , while reducing Cu 2+ to Cu 1+ , during the period when it slowly transforms into soluble oligomers ( 2 O 2 , levels decrease, suggesting that the fibrils that are ultimately formed may clear the H 2 O 2

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A portion of each brain was homogenized (1:9, tissue: buffer, w/v) in ice-cold phosphate buffer saline (0.05 M, pH 7.0) (Heidoph, Silent Crusher S, Germany)