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The distance of cancer cells migrating along nerves was calculated

Interestingly, several studies showed that cytokines and stress stimuli such as TNF-, interleukins, FAS ligand, heat shock, UV irradiation and also stressors that deplete glutathione such as ROS and 4HNE can activate sphingomyelinase, which leads to increased ceramide production 58,59,60

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It remains to be further investigated, whether it is possible to avoid blunting of the inhibitory action by other types of inhibitors, by their combination or by combination of the diverse therapeutic modalities to efficiently limit propagation of tumor cells