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Carcinogenesis, Mutagenesis, Impairment of Fertility: Long term studies in animals to evaluate carcinogenic potential have not been done

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Across GLP-1 trials, about 60% of lost weight returns within the first year and roughly 75% returns over the longer curve, with the fastest regain in the early months. In semaglutides extension, about two-thirds returned within one year. The pattern reflects removal of appetite suppression after major weight loss