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Qu et al., 2020)
As potential inducer of HEP expression, phytoestrogens are promising dietary supplements to reduce iron overload and prevent any sequelae of iron-induced toxicities such as hyperferritinemia, coagulopathies and/or thromboembolism, which are prominent clinical manifestations in COVID-19 and PASC 94,144,494,495
A detailed description of CAFs and a comparison to normal fibroblasts, as well as how the interact with the TME has previously been published (Liu et al., 2019)
However, larger, high-quality trials are still needed before it can be recommended widely
Glutathione depletion down-regulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms