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doi: 10.3389/fphar.2019.00885 Received 01 April 2019 Accepted 15 July 2019 Published 12 August 2019 Volume 10 - 2019 Edited by M Foster Olive, Arizona State University, United States Reviewed by Nicholas W

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O2- is mainly produced during cellular respiration by mitochondria, also by action of lipoxygenases (LOX) and cyclooxygenases (COX) during the arachidonic acid metabolism and by endothelial and inflammatory cells 6