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Pharm Res 30:21742187 McGill MR, Jaeschke H (2014) Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients

Liver function tests evaluate whether the liver is handling copper metabolism appropriately

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The inability to maintain reduced glutathione in RBCs leads to increased accumulation of peroxides, predominantly H 2 O 2 , that in turn results in a weakening of the cell wall as a result of membrane lipid peroxidation resulting in concomitant hemolysis

Zechmann B, Zellnig G, Urbanek-Krajnc A, Mller M (2007) Artificial elevation of glutathione affects symptom development in ZYMV-infected Cucurbita pepo L

In IMQ mouse models, resveratrol reduces erythema, scaling, and epidermal thickening, while small clinical studies suggest PASI improvement [50]